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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
20.3
Human Site:
Y140
Identified Species:
37.22
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
Y140
D
T
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
L151
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
Y140
D
T
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
Y140
D
T
S
L
D
K
F
Y
K
Q
V
I
D
K
G
Rat
Rattus norvegicus
Q4KSH7
419
47517
E204
E
L
M
G
T
C
A
E
K
L
K
K
R
M
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
Y156
D
T
S
L
D
K
F
Y
K
K
V
L
E
K
N
Chicken
Gallus gallus
Q90891
398
44059
L153
E
H
M
D
G
G
S
L
D
Q
V
L
K
E
A
Frog
Xenopus laevis
Q07192
446
50082
K237
T
S
F
D
K
F
Y
K
Y
V
Y
S
F
L
D
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
Y167
D
T
S
L
D
K
F
Y
K
Q
V
H
E
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
Y133
S
T
S
L
D
K
F
Y
P
K
V
F
L
H
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
K155
I
S
M
D
L
L
Y
K
R
V
Y
M
V
K
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
L153
E
Y
M
D
G
G
S
L
A
D
F
L
K
S
V
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
I446
D
G
G
S
L
D
K
I
Y
D
E
S
S
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
20
N.A.
100
N.A.
100
6.6
N.A.
73.3
13.3
0
86.6
N.A.
53.3
N.A.
6.6
N.A.
P-Site Similarity:
100
33.3
N.A.
100
N.A.
100
13.3
N.A.
93.3
33.3
13.3
93.3
N.A.
60
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
16
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
39
47
8
0
0
16
16
0
0
24
0
16
% D
% Glu:
31
0
0
0
0
0
0
8
0
0
8
0
16
16
0
% E
% Phe:
0
0
8
0
0
8
47
0
0
0
8
8
8
0
0
% F
% Gly:
0
8
8
8
24
24
0
0
0
0
0
0
0
0
31
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
8
0
8
0
% H
% Ile:
8
0
0
0
0
0
0
8
0
0
0
24
0
0
8
% I
% Lys:
0
0
0
0
8
47
8
16
47
16
8
8
24
54
0
% K
% Leu:
0
8
0
47
16
8
0
24
0
8
0
31
8
8
0
% L
% Met:
0
0
39
0
0
0
0
0
0
0
0
8
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% R
% Ser:
8
16
47
8
0
0
24
0
0
0
0
16
8
8
0
% S
% Thr:
8
47
0
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
16
62
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
16
47
16
0
16
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _